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Identifying and separating a subpopulation of cells from a heterogeneous mixture are essential elements of biological research. Current approaches require detailed knowledge of unique cell surface properties of the target cell population. A method is described that exploits size differences of cells to facilitate selective intracellular delivery using a high throughput microfluidic device. Cells traversing...
Immature human immunodeficiency virus type 1 (HIV‐1) is approximately spherical, but is constructed from a hexagonal lattice of the Gag protein. As a hexagonal lattice is necessarily flat, the local symmetry cannot be maintained throughout the structure. This geometrical frustration presumably results in bending stress. In natural particles, the stress is relieved by incorporation of packing defects,...
Self‐propelled Janus particles, acting as microscopic vehicles, have the potential to perform complex tasks on a microscopic scale, suitable, e.g., for environmental applications, on‐chip chemical information processing, or in vivo drug delivery. Development of these smart nanodevices requires a better understanding of how synthetic swimmers move in crowded and confined environments that mimic actual...
A high sensitivity self‐powered solar‐blind photodetector is successfully constructed based on the polyaniline/MgZnO bilayer. The maximum responsivity of the photodetector is 160 μA W−1 at 250 nm under 0 V bias. The device also exhibits a high on/off ratio of ≈104 under 250 nm illumination at a relatively weak light intensity of 130 μW cm−2 without any power.
Biological responses of cells and organisms to nanoparticle exposure crucially depend on the properties of the protein adsorption layer (“protein corona”) forming on nanoparticle surfaces and their characterization is a crucial step toward a deep, mechanistic understanding of their build‐up. Previously, adsorption of one type of model protein on nanoparticles was systematically studied in situ by...
A theranostic, enzymatically biodegradable nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT‐3 inhibitor. On page 5845, D. Pan and co‐workers reveal that, overall, the supramolecular chemistry on nanocarbon acts as a novel arsenal for STAT‐3 inhibition in vitro and in vivo and provides signature intracellular...
The budding yeast Saccharomyces cerevisiae has been a powerful model for the study of aging and has enabled significant contributions to our understanding of basic mechanisms of aging in eukaryotic cells. However, the laborious low‐throughput nature of conventional methods of performing aging assays limits the pace of discoveries in this field. Some of the technical challenges of conventional aging...
A controllable and scalable strategy is developed to fabricate multiplexed plasmonic nanoparticle structures by mechanical scratching with AFM lithography, which exhibit multiplex plasmonic properties and surface‐enhanced Raman scattering responses. It offers an intuitive way to explore the plasmonic effects on the performance of an organic light‐emitting diode device integrating with multiplexed...
Combining catalytic Janus swimmers and passive beads in narrow channels, L. Baraban and co‐workers observe many dynamic properties, ranging from distinct bulk and boundary‐free diffusivity at low densities, whereby a Janus swimmer transports large clusters of passive particles. This research (on page 5882) is an important milestone towards understanding and further fabrication of realistic bioinspired...
Signal transducer and activator of transcription factor 3 (STAT‐3) is known to be overexpressed in cancer stem cells. Poor solubility and variable drug absorption are linked to low bioavailability and decreased efficacy. Many of the drugs regulating STAT‐3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles...
The ambient environmental instability and degradation mechanism of single‐ and few‐layer WTe2 are investigated. Oxidation of W and Te atoms appears to be a main reason for degradation. Single‐layer samples' Raman signals disappear within 20 min in air. Few‐layer WTe2 exhibits saturating degradation behavior: only the top layer WTe2 is oxidized; the degraded layer can protect inner layers from further...
A thermally and mechanically robust Ag nanowire‐embedded colorless polyimide (Ag NW‐CPI) heater is developed for a substrate for wearable chemical sensors by I.‐D. Kim and co‐workers, on page 5826. Optically reduced graphene oxide (ORGO) sheets are integrated on the Ag NW‐CPI heater as a chemical sensing layer. Improved reversible NO2 reaction kinetics of ORGO sheets are achieved by heat generation...
Optically reduced graphene oxide (ORGO) sheets are successfully integrated on silver nanowire (Ag NW)‐embedded transparent and flexible substrate. As a heating element, Ag NWs are embedded in a colorless polyimide (CPI) film by covering Ag NW networks using polyamic acid and subsequent imidization. Graphene oxide dispersed aqueous solution is drop‐coated on the Ag NW‐embedded CPI (Ag NW‐CPI) film...
A scalable strategy to fabricate multiplexed plasmonic nanoparticle structures by mechanical scratching with AFM (atomic force microscopy) lithography is presented by L. Jiang, L. Chi, and co‐workers, on page 5818. Under the assistance of polymer resist, different shapes of gold nanoparticles assembled on the silicon substrate can be directly scratched by an AFM tip to form well defined nanostructures...
The geometrical prerequisite for forming a helix is P (helical pitch) > d (wire diameter). Limited by the current development of nanofabrication techniques, it is difficult to minimize d and consequently P to the sub‐10 nm molecule‐comparable scale, preventing the study of chiral plasmonics at dimensions approaching the physical limit. Herein, glancing angle deposition is operated at substrate...
The assembly of plasmonic metal nanoparticles into hot spot surface‐enhanced Raman scattering (SERS) nanocluster probes is a powerful, yet challenging approach for ultrasensitive biosensing. Scaffolding strategies based on self‐complementary peptides and proteins are of increasing interest for these assemblies, but the electronic and the photonic properties of such hybrid nanoclusters remain difficult...
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